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People who live with osteoarthritis experience knee joint pain due to damaged tissues called cartilage. The body weight or load bearing weight that strains the mechanics of this joint from everyday activities such as walking, and climbing stairs impacts the overall health and recovery of the cartilage.

Our work focusses on measuring biomarkers in individuals with knee osteoarthritis and other conditions that put them at harm or risk of cartilage disease. We are able to study these measurements from extracted joint fluids, blood and urine. The biological measurements may provide information on the metabolic state of the knee cartilage and how some physical activities may influence the future of their knee joint health.

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• The Development of a Cartilage Stress test, (using a lateral tilt paradigm) for knee Osteoarthritis 
  Co-Investigators: Chad Hanaoka BA (Northwestern), Nicholas Gornick PT (Shirley Ryan ³Ô¹ÏÌìÌÃ91), Levi Hargrove PhD (Shirley Ryan ³Ô¹ÏÌìÌÃ91), Vikram Dharbe (Shirley Ryan ³Ô¹ÏÌìÌÃ91)
   
•  Impact of Anti-Gravity Treadmill Walking for Knee Osteoarthritis
  Co-Investigators: Chad Hanaoka BA (Northwestern), Nicholas Gornick PT (Shirley Ryan ³Ô¹ÏÌìÌÃ91), Levi Hargrove PhD (Shirley Ryan ³Ô¹ÏÌìÌÃ91), Vikram Dharbe (Shirley Ryan ³Ô¹ÏÌìÌÃ91)
   
• Development of a Biomarker Panel of Joint disease in adolescents or young adults with cerebral Palsy
  Co-investigators: Chad Hanaoka BA (Northwestern), Deborah Gaebler MD, Benjamin Katholi MD (Shirley Ryan ³Ô¹ÏÌìÌÃ91)
   
• Cartilage Atrophy in Individuals with Acute Spinal Cord Injury
  Co-investigators: Alexandra Haselhorst DO (UT Austin), Ben Washburn MD, Sushil Singla MD (Shirley Ryan ³Ô¹ÏÌìÌÃ91)
   
• The Acute Impact of Walking the Course vs. Golf Cart Use on Biomarkers of Osteoarthritis and Joint Pain in Individuals with Knee Osteoarthritis 
  Co-investigators: Rachel Bergman BA (U of Michigan Medical School), Emilio Jauregui (USC), Aaron Stoker PhD (U of Missouri)
  • Video: Knee Osteoarthritis Golf Research Study
     
• Changes in Biomarkers in Response to Fluoroscopic versus Ultrasound-Guided Genicular Nerve Radiofrequency Ablation for Knee Osteoarthritis
  Co-investigators: Daniel Herman MD (U. Florida), Katherine Rizzone MD